Invention Grant
- Patent Title: Triazole derivatives as Wnt signaling pathway inhibitors
- Patent Title (中): 三唑衍生物作为Wnt信号通路抑制剂
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Application No.: US13992879Application Date: 2011-12-08
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Publication No.: US09096587B2Publication Date: 2015-08-04
- Inventor: Daniel Holsworth , Jo Waaler , Ondrej Machon , Stefan Krauss , Andrey Edward Voronkov
- Applicant: Daniel Holsworth , Jo Waaler , Ondrej Machon , Stefan Krauss , Andrey Edward Voronkov
- Applicant Address: NO
- Assignee: OSLO UNIVERSITY HOSPITAL HF
- Current Assignee: OSLO UNIVERSITY HOSPITAL HF
- Current Assignee Address: NO
- Agency: Cantor Colburn LLP
- International Application: PCT/GB2011/052441 WO 20111208
- International Announcement: WO2012/076898 WO 20120614
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D413/14 ; A61K31/5377
Abstract:
The present invention relates to compounds of formula (I), to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy: Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway and increased presence of nuclear β-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas.
Public/Granted literature
- US20140031374A1 TRIAZOLE DERIVATIVES AS WNT SIGNALING PATHWAY INHIBITORS Public/Granted day:2014-01-30
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