Invention Grant
US09096602B2 Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors
有权
取代的吡咯并[2,3-B]吡嗪作为ATR激酶抑制剂
![Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors](/docs/US/2015-08-04/US09096602B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors
- Patent Title (中): 取代的吡咯并[2,3-B]吡嗪作为ATR激酶抑制剂
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Application No.: US13531464Application Date: 2012-06-22
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Publication No.: US09096602B2Publication Date: 2015-08-04
- Inventor: Simon Everitt , Michael Paul Mortimore , Jean-Damien Charrier , Somhairle MacCormick , Pierre-Henri Storck , Ronald Knegtel , Joanne Pinder , Steven John Durrant
- Applicant: Simon Everitt , Michael Paul Mortimore , Jean-Damien Charrier , Somhairle MacCormick , Pierre-Henri Storck , Ronald Knegtel , Joanne Pinder , Steven John Durrant
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agent Booyong S. Lim
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; C07D487/04
![Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors](/abs-image/US/2015/08/04/US09096602B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
Public/Granted literature
- US20130017273A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE Public/Granted day:2013-01-17
Information query
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