Invention Grant
- Patent Title: Fused heterocyclic derivatives as S1P modulators
- Patent Title (中): 稠合杂环衍生物作为S1P调节剂
-
Application No.: US14019236Application Date: 2013-09-05
-
Publication No.: US09096612B2Publication Date: 2015-08-04
- Inventor: Pieter Smid , Wouter I. Iwema Bakker , Hein K. A. C. Coolen , Leonardus A. J. M. Sliedregt , Maria J. P. van Dongen , Jacobus A. J. den Hartog , Adrian Hobson
- Applicant: Abbvie B.V. , AbbVie, Inc.
- Applicant Address: NL Hoofddorp US IL North Chicago
- Assignee: AbbVie B.V.,AbbVie Inc.
- Current Assignee: AbbVie B.V.,AbbVie Inc.
- Current Assignee Address: NL Hoofddorp US IL North Chicago
- Agency: Michael Best & Friedrich LLP
- Agent Lisa V. Mueller
- Priority: EP10169107 20100709; EP11156007 20110225
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A01N43/46 ; C07D513/04 ; C07D487/04 ; C07D491/04 ; C07D498/04 ; C07D471/04 ; C07D491/048 ; C07D495/04
Abstract:
The present invention relates to a fused heterocyclic derivative of the formula (I) The variables R1-R4, z, A, Q, X and Y are as defined in the claims. The following heterocycles are exemplified sub-structures of formula (I): The compounds of formula (I) are modulators of the S1P receptor (Sphingosine-1-phosphate receptor), More specifically, they are agonists of S1P5. The compounds have therapeutic use in treatment of cognitive disorders, age-relate cognitive decline and dementia.
Public/Granted literature
- US20140066433A1 FUSED HETEROCYCLIC DERIVATIVES AS S1P MODULATORS Public/Granted day:2014-03-06
Information query
IPC分类:
