Invention Grant
US09096640B2 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-diene-11-methylene oxyalkylene aryl derivatives, process for preparation thereof, and use thereof for treatment of diseases
有权
17-羟基-17-五氟乙基 - 雌-4,9（10） - 二烯-11-亚甲基氧亚烷基芳基衍生物，其制备方法及其用于治疗疾病的用途
- Patent Title: 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-diene-11-methylene oxyalkylene aryl derivatives, process for preparation thereof, and use thereof for treatment of diseases
- Patent Title (中): 17-羟基-17-五氟乙基 - 雌-4,9（10） - 二烯-11-亚甲基氧亚烷基芳基衍生物，其制备方法及其用于治疗疾病的用途
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Application No.: US13384765Application Date: 2010-07-07
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Publication No.: US09096640B2Publication Date: 2015-08-04
- Inventor: Ulrich Klar , Wolfgang Schwede , Carsten Möller , Andrea Rotgeri , Wilhelm Bone
- Applicant: Ulrich Klar , Wolfgang Schwede , Carsten Möller , Andrea Rotgeri , Wilhelm Bone
- Applicant Address: DE Monheim
- Assignee: Bayer Intellectual Property
- Current Assignee: Bayer Intellectual Property
- Current Assignee Address: DE Monheim
- Agent Karen B. King; Thomas C. Blankinship
- Priority: DE102009034366 20090720
- International Application: PCT/EP2010/004146 WO 20100707
- International Announcement: WO2011/009529 WO 20110127
- Main IPC: A61K31/567
- IPC: A61K31/567 ; C07J1/00 ; C07J7/00 ; C07J41/00 ; C07J43/00 ; A61K31/573
Abstract:
The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-diene-11-methyleneoxyalkylenearyl derivative of the formula I with progesterone-antagonising action and to processes for preparation thereof, to use thereof for treatment and/or prophylaxis of disorders and to the use thereof for production of medicaments for treatment and/or prophylaxis of disorders, especially of fibroids of the uterus (myomas, uterine leiomyomas), endometriosis, heavy menstrual bleeds, meningiomas, hormone-dependent breast cancers and complaints associated with the menopause, or for fertility control and emergency contraception.
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