Invention Grant
US09096645B2 Dipeptide analogs for treating conditions associated with amyloid fibril formation
有权
用于治疗与淀粉样蛋白原纤维形成相关的病症的二肽类似物
- Patent Title: Dipeptide analogs for treating conditions associated with amyloid fibril formation
- Patent Title (中): 用于治疗与淀粉样蛋白原纤维形成相关的病症的二肽类似物
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Application No.: US13884989Application Date: 2011-11-15
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Publication No.: US09096645B2Publication Date: 2015-08-04
- Inventor: Ehud Gazit , Yaniv Amir , Ludmila Buzhansky , Ulrich Abel , Anat Frydman-Marom
- Applicant: Ehud Gazit , Yaniv Amir , Ludmila Buzhansky , Ulrich Abel , Anat Frydman-Marom
- Applicant Address: IL Tel-Aviv
- Assignee: Ramot at Tel-Aviv University Ltd.
- Current Assignee: Ramot at Tel-Aviv University Ltd.
- Current Assignee Address: IL Tel-Aviv
- Priority: EP10191253 20101115
- International Application: PCT/IL2011/050010 WO 20111115
- International Announcement: WO2012/066549 WO 20120524
- Main IPC: A61K38/05
- IPC: A61K38/05 ; C07D209/20 ; C07K5/078
Abstract:
Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipeptide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.
Public/Granted literature
- US20130225512A1 DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION Public/Granted day:2013-08-29
Information query
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