Invention Grant
- Patent Title: CXCR4 receptor compounds
- Patent Title (中): CXCR4受体化合物
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Application No.: US13127443Application Date: 2009-11-04
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Publication No.: US09096646B2Publication Date: 2015-08-04
- Inventor: Thomas J. McMurry , Athan Kuliopulos , Lidija Covic , Boris Tchernychev
- Applicant: Thomas J. McMurry , Athan Kuliopulos , Lidija Covic , Boris Tchernychev
- Applicant Address: US MA Cambridge
- Assignee: Anchor Therapeutics, Inc.
- Current Assignee: Anchor Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- International Application: PCT/US2009/005979 WO 20091104
- International Announcement: WO2010/053550 WO 20100514
- Main IPC: C07K7/08
- IPC: C07K7/08 ; C07K14/715 ; C07K7/06 ; A61K38/00
Abstract:
The invention relates generally to compounds which are allosteric modulators (e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease, inflammatory diseases, HIV infection and stem cell-based regenerative medicine.
Public/Granted literature
- US20130210709A1 CXCR4 Receptor Compounds Public/Granted day:2013-08-15
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