Invention Grant
US09096663B2 Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
有权
用于氧化还原蛋白及其突变体治疗与ephrin信号传导相关的病症的组合物和方法
- Patent Title: Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
- Patent Title (中): 用于氧化还原蛋白及其突变体治疗与ephrin信号传导相关的病症的组合物和方法
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Application No.: US12013122Application Date: 2008-01-11
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Publication No.: US09096663B2Publication Date: 2015-08-04
- Inventor: Anita Chaudhari , Ananda Chakrabarty , Tapas Das Gupta , Arsenio Fialho , Tohru Yamada , Yonghua Zhu
- Applicant: Anita Chaudhari , Ananda Chakrabarty , Tapas Das Gupta , Arsenio Fialho , Tohru Yamada , Yonghua Zhu
- Applicant Address: US IL Urbana
- Assignee: The Board of Trustees of the University of Illinois
- Current Assignee: The Board of Trustees of the University of Illinois
- Current Assignee Address: US IL Urbana
- Agency: Sheppard, Mullin, Richter & Hampton LLP
- Agent Don J. Pelto, Esq.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/00 ; A61P35/00 ; C07K14/21 ; C07K14/52 ; C07K14/705
Abstract:
The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals. The invention specifically includes mutants with altered Eph binding constants and selectivities.
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