Invention Grant
- Patent Title: Inhibition of inflammation using antagonists of MUC1
- Patent Title (中): 使用MUC1拮抗剂抑制炎症
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Application No.: US14138521Application Date: 2013-12-23
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Publication No.: US09096687B2Publication Date: 2015-08-04
- Inventor: Donald W. Kufe , Surender Kharbanda
- Applicant: DANA-FARBER CANCER INSTITUTE, INC. , GENUS ONCOLOGY, LLC
- Applicant Address: US IL Chicago US MA Boston
- Assignee: Genus Oncology, LLC,Dana-Farber Cancer Institute, Inc.
- Current Assignee: Genus Oncology, LLC,Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US IL Chicago US MA Boston
- Agency: Parker Highlander PLLC
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/00 ; A61P29/00 ; C07K14/705 ; A61K38/17 ; A61K45/06 ; C07K14/47
Abstract:
The invention provides for peptides from the MUC1 cytoplasmic domain and methods of use therefor. These peptides can inhibit MUC1 oligomerization, inhibit the interaction of MUC1 with NF-κB or a STAT, and block inflammatory response mediated by NF-κB or STAT signaling.
Public/Granted literature
- US20140187494A1 INHIBITION OF INFLAMMATION USING ANTAGONISTS OF MUC1 Public/Granted day:2014-07-03
Information query
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