Method of operating a wind power plant including the steps of: operating the wind power plant at an current parameter schedule (Pcurrent(v)) performing a wind prediction of wind data (Vw) for a time frame (ΔT) extending to a future time T, determining a desired fatigue load level (Fdesired) of a wind power plant component at the future time T, and during operation of said wind power plant generating an updated parameter schedule (Pdesired(v)) to provide the desired fatigue load level (Fdesired) at time T if exposed to the predicted wind conditions (Vw(t)) during said time frame (ΔT).