Systems and methods for airborne object detection using monocular sensors are provided. In one embodiment, a system for detecting moving objects from a mobile vehicle comprises: an imaging camera; a navigation unit including at least an inertial measurement unit; and a computer system coupled to the image camera and the navigation unit. The computer system executes an airborne object detection process algorithm, and calculates a transformation between two or more image frames captured by the imaging camera using navigation information associated with each of the two or more image frames to generate a motion compensated background image sequence. The computer system detects moving objects from the motion compensated background image sequence.