A system-on-chip including a host interface module configured to interface the system-on-chip to a host processor of a wireless device and to communicate with the host processor of the wireless device via a bus. The bus uses an application programming interface of the system-on-chip. The host processor uses the application programming interface to configure a power save mode of the system-on-chip. A power management module operated the system-on-chip in the power save mode without performing a handshake with the host processor via the bus in response to the host processor stopping communication with the system-on-chip. The handshake includes (i) sending a request to enter the power save mode to the host processor via the bus and (ii) receiving an acknowledgement of the request from the host processor via the bus.