A fishing reel having a centrifugal brake system is provided. The fishing reel includes a frame, a shaft, a spool and a centrifugal brake system. The centrifugal brake system includes a support member, a plurality of brake shoes, a brake disc and a controller. The support member is provided on one side of the spool and is rotated in conjunction with the spool. The brake shoes are radially coupled to the support member by respective shaft pins. Each brake shoe has a heavy weight part and a light weight part on opposite sides based on the shaft pin to have a weight eccentric structure. When the spool is rotated, the brake shoes are swung by centrifugal force. The controller adjusts a distance between the brake disc and the brake shoes, thus controlling braking power.