The present invention relates to a locking system designed for packages intended particularly for packing make-up comprising refills without the use of adhesives. The locking system for packages comprises:—a base (1) having a side wall (11);—a cover (3) cooperating with the base (1);—a refill (2) composed by at least one first cavity (4); said locking system being characterized in that:—the refill (2) comprises at least one first securing means (21) in the form of a side projection facing outwardly and a second securing means (22) in the form of a side projection facing outwardly and having a curved end;—the first securing means (21) being opposed to the second securing means (22);—the side wall (11) having at least one first opening (12) cooperating with the first securing means (21) and a second opening (13) cooperating with the second securing means (22);—the refill (2) being fitted into the base (1) by association between the first securing means (21) and the first opening (12) and then association between the second securing means (22) and the second opening (13). The present invention further relates to packages comprising said locking system and the refill comprised in this system.