Invention Grant
- Patent Title: Dissolution stability of calcium carbonate tablets
- Patent Title (中): 碳酸钙片的溶解稳定性
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Application No.: US13129664Application Date: 2009-11-17
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Publication No.: US09101565B2Publication Date: 2015-08-11
- Inventor: Peder Mohr Olsen , Poul Egon Bertelsen , Thomas Thisted , Henrik Ravn Aage
- Applicant: Peder Mohr Olsen , Poul Egon Bertelsen , Thomas Thisted , Henrik Ravn Aage
- Applicant Address: NO Asker
- Assignee: TAKEDA NYCOMED AS
- Current Assignee: TAKEDA NYCOMED AS
- Current Assignee Address: NO Asker
- Agency: Choate, Hall & Stewart LLP
- Agent Charles E. Lyon; Kevin M. Henry
- Priority: EP08169264 20081117
- International Application: PCT/EP2009/008157 WO 20091117
- International Announcement: WO2010/054845 WO 20100520
- Main IPC: A61K33/10
- IPC: A61K33/10 ; A61K47/26 ; A61K33/06 ; A61K9/20

Abstract:
The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.
Public/Granted literature
- US20110287098A1 DISSOLUTION STABILITY OF CALCIUM CARBONATE TABLETS Public/Granted day:2011-11-24
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