Invention Grant
US09101616B2 Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
有权
芳基取代的甲酰胺衍生物作为钙或钠通道阻断剂
- Patent Title: Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
- Patent Title (中): 芳基取代的甲酰胺衍生物作为钙或钠通道阻断剂
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Application No.: US13375117Application Date: 2010-05-31
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Publication No.: US09101616B2Publication Date: 2015-08-11
- Inventor: Tadashi Inoue , Shuzo Watanabe , Tatsuya Yamagishi , Yoshimasa Arano , Mikio Morita , Kaoru Shimada
- Applicant: Tadashi Inoue , Shuzo Watanabe , Tatsuya Yamagishi , Yoshimasa Arano , Mikio Morita , Kaoru Shimada
- Applicant Address: JP Aichi
- Assignee: RaQualia Pharma Inc.
- Current Assignee: RaQualia Pharma Inc.
- Current Assignee Address: JP Aichi
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- International Application: PCT/JP2010/003649 WO 20100531
- International Announcement: WO2010/137351 WO 20101202
- Main IPC: A61K31/498
- IPC: A61K31/498 ; C07D401/12 ; C07D213/65 ; C07D241/18 ; A61K31/497 ; A61K31/444 ; A61K31/44 ; A61K31/4965 ; A61K31/4439 ; A61K31/4709 ; C07D413/12 ; A61K31/4725 ; A61K31/443 ; A61K31/4433 ; A61K31/4436 ; A61K31/4706 ; A61K31/506 ; C07D215/40 ; C07D401/14 ; C07D405/12 ; C07D409/12 ; C07D417/12

Abstract:
The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blockers such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.
Public/Granted literature
- US20120101105A1 ARYL SUBSTITUTED CARBOXAMIDE DERIVATIVES AS CALCIUM OR SODIUM CHANNEL BLOCKERS Public/Granted day:2012-04-26
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