Invention Grant
- Patent Title: Inhibitors of filovirus entry into host cells
- Patent Title (中): 叶病毒进入宿主细胞的抑制剂
-
Application No.: US13383345Application Date: 2010-07-10
-
Publication No.: US09101635B2Publication Date: 2015-08-11
- Inventor: Arnab Basu , Debra M. Mills , Norton P. Peet , John D. Williams
- Applicant: Arnab Basu , Debra M. Mills , Norton P. Peet , John D. Williams
- Applicant Address: US MA Worcester
- Assignee: MICROBIOTIX, INC.
- Current Assignee: MICROBIOTIX, INC.
- Current Assignee Address: US MA Worcester
- Agency: Yankwich & Associates, P.C.
- Agent Leon R. Yankwich; Michael R. Wesolowski
- International Application: PCT/US2010/041632 WO 20100710
- International Announcement: WO2011/046646 WO 20110421
- Main IPC: A61K31/18
- IPC: A61K31/18 ; A61K31/5513 ; C07D213/74 ; C07D215/40 ; C07D243/12 ; C07D249/10 ; C07D307/71 ; C07D405/06 ; C07D405/12 ; C07D405/14 ; C07D409/04 ; C07D471/04 ; C07D491/22
Abstract:
Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.
Public/Granted literature
- US20120189614A1 INHIBITORS OF FILOVIRUS ENTRY INTO HOST CELLS Public/Granted day:2012-07-26
Information query
