A system for dialysis is disclosed. The system uses renal failure therapy fluid, such as dialysis fluid, several times before it is discarded. In a home hemodialysis application, the patient's blood is passed through the dialyzer several times, that is, multiple passes through the dialyzer, until the dialysis fluid is saturated or near saturation, with waste products from the patient's blood. In peritoneal dialysis, the dialysate is used at least twice within the patient's peritoneal cavity, i.e., multiple passes, before it is discarded. This has the effect minimizing the amount of dialysate a patient must handle and dispose of in the dialysis process.