Invention Grant
- Patent Title: Stem cell immune modulation methods of use and apparatus
- Patent Title (中): 干细胞免疫调节方法的使用和装置
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Application No.: US13514694Application Date: 2010-12-08
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Publication No.: US09101726B2Publication Date: 2015-08-11
- Inventor: Yong Zhao
- Applicant: Yong Zhao
- Applicant Address: US IL Urbana
- Assignee: The Board of Trustees of the University of Illinois
- Current Assignee: The Board of Trustees of the University of Illinois
- Current Assignee Address: US IL Urbana
- Agency: Greenberg Traurig, LLP
- Agent Weisun Rao
- International Application: PCT/US2010/059522 WO 20101208
- International Announcement: WO2011/087637 WO 20110721
- Main IPC: A61M37/00
- IPC: A61M37/00 ; A61M1/34 ; C12N5/078 ; C12M1/12 ; C12M1/42 ; A61K35/12

Abstract:
Methods and apparatus are disclosed co-culturing stem cells with mononuclear cells and/or lymphocytes to modulate their function. The invention also discloses the use of stem cells to educate autoreactive immune cells as a mechanism to treat autoimmune diseases and immune disorder-related diseases, such as diabetes. In one aspect of the invention, bioreactors are disclosed closed for modulating lymphocytes and suppressing autoreactive T cells. The bioreactors can include a chamber having at least one positively charged and/or hydrophobic substrate surface, a population of stem cells attached to the substrate surface, an inlet conduit for introducing lymphocytes into the chamber, and an outlet conduit for extracting treated lymphocytes following co-culturing with the stem cells.
Public/Granted literature
- US20120277652A1 Stem Cell Immune Modulation Methods of Use and Apparatus Public/Granted day:2012-11-01
Information query
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