Embodiments of a welding wire feeder including a pushbutton wire guide holder are provided. The wire guide holder may allow for the insertion and removal of a welding wire guide by depression of a spring-biased pushbutton and hold the wire guide with force applied by a spring. The pushbutton is disposed in a body, and a stop placed in contact with the pushbutton may prevent the pushbutton from being forced out of the body by the spring force. Some embodiments are directed toward holding inlet wire guides or intermediate wire guides, and therefore include different configurations of the body, pushbutton, spring, and stop.