A combinational tool holder device has a holder base, a first combination holder and a second combination holder. An inner tube of the holder base has multiple longitudinal insertion holes longitudinally formed in the inner tube and multiple radial insertion troughs radially formed in the inner tube and respectively communicating with the longitudinal insertion holes. The first combination holder and the second combination holder are mounted around the holder base and both have tool insertion holes. The first combination holder clamps the holder base by two first holder claws, and the second combination holder clamps the holder base by two second holder claws. A first interval between the two second holder claws is larger than a second interval between the two first holder claws.