Invention Grant
US09102635B2 Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
有权
取代的双苯基丁酸衍生物作为具有改善的体内功效的NEP抑制剂
- Patent Title: Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
- Patent Title (中): 取代的双苯基丁酸衍生物作为具有改善的体内功效的NEP抑制剂
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Application No.: US14178312Application Date: 2014-02-12
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Publication No.: US09102635B2Publication Date: 2015-08-11
- Inventor: David Weninger Barnes , Dean Franklin Rigel
- Applicant: David Weninger Barnes , Dean Franklin Rigel
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agency: Sophie Binet Cross
- Main IPC: C07D271/113
- IPC: C07D271/113 ; A61K31/4245 ; A61K45/06
Abstract:
The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein X is defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.
Public/Granted literature
- US20140228415A1 Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo Efficacy Public/Granted day:2014-08-14
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