Invention Grant
US09102752B2 Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type 有权
用于预防和免疫治疗阿尔茨海默氏型痴呆的肽疫苗

Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type
Abstract:
The present disclosure is directed to individual Aβ peptide immunogen constructs, peptide compositions comprising these Aβ peptide immunogen constructs and mixtures thereof, pharmaceutical compositions including vaccine formulations comprising these Aβ peptide immunogen constructs, with the individual Aβ peptide immunogen constructs having the N-terminus of the Aβ peptide as the B cell (B) epitopes linked through spacer residue(s) to heterologous T helper cell (Th) epitopes derived from pathogen proteins that act together to stimulate the generation of highly specific antibodies directed against the N-terminus of the Aβ peptide offering protective immune responses to patients at risk for, or with, Alzheimer's Disease.
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