Invention Grant
- Patent Title: Synthesis of sialooligosaccharide derivatives
- Patent Title (中): 唾液寡糖衍生物的合成
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Application No.: US13809794Application Date: 2011-07-15
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Publication No.: US09102966B2Publication Date: 2015-08-11
- Inventor: Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
- Applicant: Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
- Applicant Address: DK KGS, Lyngby
- Assignee: GLYCOM A/S
- Current Assignee: GLYCOM A/S
- Current Assignee Address: DK KGS, Lyngby
- Agency: Pillsbury Winthrop Shaw Pittman LLP
- Priority: GB1012036.8 20100716; EP11166036 20110513
- International Application: PCT/EP2011/062184 WO 20110715
- International Announcement: WO2012/007588 WO 20120119
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C12P19/14 ; C12P19/44 ; C12P19/18 ; C07H1/06 ; C07H3/06 ; C12P19/26
Abstract:
The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.
Public/Granted literature
- US20130171696A1 SYNTHESIS OF NEW SIALOOLIGOSACCHARIDE DERIVATIVES Public/Granted day:2013-07-04
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