According to some embodiments, a thermoelectric system includes a plurality of thermoelectric elements forming a thermoelectric array, the thermoelectric elements having a cooling side and a heating side. The system further includes at least one heat exchanger on at least one of the cooling side and the heating side, the heat exchanger being in thermal communication with at least some of the thermoelectric elements. In addition, the system includes a substrate generally positioned between the thermoelectric elements and the heat exchange element. The substrate comprises an electrical isolation layer, a support element configured to receive the heat exchanger and a plurality of interconnecting tabs configured to place adjacent thermoelectric elements in electrical communication with one another.