Described are systems and methods performed by computer to reduce crosstalk produced by loudspeakers when rendering binaural sound that is emitted from the loudspeakers into a room. The room may have sound-reflecting surfaces that reflect some of the sound produced by the loudspeakers. To reduce crosstalk, a room model stored by the computer, is accessed. The room model models at least sound reflected by one or more of the physical surfaces. The room model is used to calculate a model of an audio channel from the loudspeakers to a listener. The model of the audio channel models sound transmission from the loudspeakers to the listener. The computer uses the model of the audio channel to cancel crosstalk from the loudspeakers when rendering the binaural sound.