Embodiments of a method and system for supporting co-existence of first and second cellular networks in adjacent channels in the same geographical area are provided. The method and system synchronize the two cellular networks such that their respective uplink transmissions are aligned in time and their respective downlink transmissions are aligned in time. Such synchronization prevents (or substantially prevents) the uplink transmissions from one of the two cellular networks from overlapping with the downlink transmissions of the other cellular network, and vice versa, thereby mitigating interference between the two networks.