Invention Grant
US09108928B2 Crystal of 5-hydroxy-1H-imidazole-4-carboxamide 3/4 hydrate, method for producing the same and crystal of 5-hydroxy-1H-imidazole-4-carboxamide hydrate
有权
5-羟基-1H-咪唑-4-甲酰胺3/4水合物的晶体，其制备方法和5-羟基-1H-咪唑-4-甲酰胺水合物的结晶
- Patent Title: Crystal of 5-hydroxy-1H-imidazole-4-carboxamide 3/4 hydrate, method for producing the same and crystal of 5-hydroxy-1H-imidazole-4-carboxamide hydrate
- Patent Title (中): 5-羟基-1H-咪唑-4-甲酰胺3/4水合物的晶体，其制备方法和5-羟基-1H-咪唑-4-甲酰胺水合物的结晶
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Application No.: US14226364Application Date: 2014-03-26
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Publication No.: US09108928B2Publication Date: 2015-08-18
- Inventor: Taisuke Fujimoto , Tomohiro Hashimoto , Katsuyuki Hayashi , Tomoyuki Tanaka
- Applicant: FUJIFILM Corporation
- Applicant Address: JP Tokyo
- Assignee: FUJIFILM Corporation
- Current Assignee: FUJIFILM Corporation
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2011-213500 20110928; JP2011-213501 20110928
- Main IPC: C07D233/90
- IPC: C07D233/90 ; A61K31/4164
Abstract:
Provided is a method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, including: reacting 2-aminomalonamide with a compound represented by the following formula [1] in the presence of a carboxylic acid to obtain 5-hydroxy-1H-imidazole-4-carboxamide: wherein, in formula [1], each R independently represents a C1-3 alkyl group; reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide with an acidic compound to obtain a 5-hydroxy-1H-imidazole-4-carboxamide acid salt or a hydrate thereof; and reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide acid salt or hydrate thereof with a salt in the presence of an acidic solvent to obtain the 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate.
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