Invention Grant
US09109223B2 Methods for generating and screening fusion protein libraries and uses thereof
有权
用于产生和筛选融合蛋白文库的方法及其用途
- Patent Title: Methods for generating and screening fusion protein libraries and uses thereof
- Patent Title (中): 用于产生和筛选融合蛋白文库的方法及其用途
-
Application No.: US12097419Application Date: 2006-12-22
-
Publication No.: US09109223B2Publication Date: 2015-08-18
- Inventor: Adrian Schwartz Mittelman , Jeannick Cizeau , Nicholas Ronald Glover , Glen Christopher MacDonald
- Applicant: Adrian Schwartz Mittelman , Jeannick Cizeau , Nicholas Ronald Glover , Glen Christopher MacDonald
- Applicant Address: CA
- Assignee: Viventia Bio, Inc.
- Current Assignee: Viventia Bio, Inc.
- Current Assignee Address: CA
- Agency: Cooley LLP
- International Application: PCT/CA2006/002113 WO 20061222
- International Announcement: WO2007/071061 WO 20070628
- Main IPC: C40B30/04
- IPC: C40B30/04 ; C12N15/10 ; C07K16/30 ; C12P21/02 ; G01N33/50
Abstract:
The invention provides methods for generating fusion protein libraries, such as immunotoxin libraries. The invention also relates to libraries of recombinant cells encoding nucleic acid sequences comprising fusion proteins. In addition, the invention relates to the libraries themselves and the use of the libraries to screen for fusion proteins that are specific for target cells, such as cancer cells. Further, the invention relates to methods of improving fusion proteins and to the improved fusion proteins.
Public/Granted literature
- US20090075878A1 Methods for Generating and Screening Fusion Protein Libraries and Uses Thereof Public/Granted day:2009-03-19
Information query
