A pixel structure adapted to a vertical alignment (VA) mode liquid crystal display (LCD) device is provided. The pixel structure includes a plurality of comb-shaped electrodes and a plurality of pixel transistors. The comb-shaped electrodes are interdigitated in a pairwise manner and thereby constitute at least one comb-shaped electrode pair. The pixel transistors respectively are electrically coupled to the comb-shaped electrodes. The comb-shaped electrodes respectively are electrically coupled to receive a plurality of data voltages through the respective pixel transistors and whereby at least a part of the data voltages are different, and the data voltages received by the two comb-shaped electrodes of each comb-shaped electrode pair are different from each other. Moreover, a VA mode LCD device using the pixel structure and a pixel driving method adapted thereto are also provided.