Invention Grant
US09119782B2 Drug delivery means 有权
药物输送方式

  • Patent Title: Drug delivery means
  • Patent Title (中): 药物输送方式
  • Application No.: US11725831
    Application Date: 2007-03-20
  • Publication No.: US09119782B2
    Publication Date: 2015-09-01
  • Inventor: Mary P. McCourt
  • Applicant: Mary P. McCourt
  • Agent Henry D. Coleman; R. Neil Sudol
  • Main IPC: A61K9/127
  • IPC: A61K9/127
Drug delivery means
Abstract:
The invention broadly comprises a chemical composition including a plurality of cholesteryl esters arranged to form a vesicle. In several embodiments, all of the plurality of cholesteryl esters have a same molecular length, which in some embodiments provides a vesicle having a generally smooth outer surface, while in other embodiments, a portion of the plurality of cholesteryl esters have different molecular lengths, which in some embodiments provides a vesicle having a generally irregular outer surface. In yet further embodiments, a shape of the vesicle is selected from the group consisting of spherical, oval, disc-like, tubular and polyhedral shapes, and in yet other embodiments, a wall of the vesicle is selected from the group consisting of a monolayer and a bilayer. In still further embodiments, the chemical composition further includes a polyethylene glycol coat of mixed polymer size. In some embodiments, the plurality of cholesteryl esters include at least two different cholesteryl esters, and in some of these embodiments, the at least two different cholesteryl esters are selected from the group consisting of: cholesteryl myristate, cholesteryl laurate, cholesteryl dodeconate, cholesteryl palmitate, cholesteryl arachidonate, cholesteryl behenate, cholesteryl linoleate, cholesteryl linolenate, cholesteryl oleate and cholesteryl stearate.
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