Invention Grant
- Patent Title: Process to form a tablet and apparatus suitable for applying this process
- Patent Title (中): 形成适用于该方法的片剂和装置的方法
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Application No.: US13266510Application Date: 2010-04-28
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Publication No.: US09119794B2Publication Date: 2015-09-01
- Inventor: Hans Almer Middelbeek , Jozefus A. C. Smit
- Applicant: Hans Almer Middelbeek , Jozefus A. C. Smit
- Applicant Address: NL Boxmeer
- Assignee: Intervet International B.V.
- Current Assignee: Intervet International B.V.
- Current Assignee Address: NL Boxmeer
- Priority: EP09159040 20090429
- International Application: PCT/EP2010/055679 WO 20100428
- International Announcement: WO2010/125084 WO 20101104
- Main IPC: B29C39/38
- IPC: B29C39/38 ; B65D85/00 ; B28B7/42 ; A61K9/20 ; A61J3/10 ; A61J7/00 ; A61K9/00

Abstract:
The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.
Public/Granted literature
- US20120049412A1 PROCESS TO FORM A TABLET AND APPARATUS SUITABLE FOR APPLYING THIS PROCESS Public/Granted day:2012-03-01
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