Invention Grant
US09119804B2 Live attenuated bordetella strains as a single dose vaccine against whooping cough
有权
活的减毒博来氏菌菌株作为单剂量疫苗针对百日咳
- Patent Title: Live attenuated bordetella strains as a single dose vaccine against whooping cough
- Patent Title (中): 活的减毒博来氏菌菌株作为单剂量疫苗针对百日咳
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Application No.: US12224895Application Date: 2007-03-07
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Publication No.: US09119804B2Publication Date: 2015-09-01
- Inventor: Camille Locht , Nathalie Mielcarek , Anne-Sophie Debrie , Dominique Raze , Julie Bertout
- Applicant: Camille Locht , Nathalie Mielcarek , Anne-Sophie Debrie , Dominique Raze , Julie Bertout
- Applicant Address: FR FR
- Assignee: Institut Pasteur de Lille,Institut National de la Sante et da la Recherche Medicale
- Current Assignee: Institut Pasteur de Lille,Institut National de la Sante et da la Recherche Medicale
- Current Assignee Address: FR FR
- Agent Stanley A. Kim
- International Application: PCT/EP2007/001942 WO 20070307
- International Announcement: WO2007/104451 WO 20070920
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K39/02 ; A61K39/00
Abstract:
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
Public/Granted literature
- US20090246222A1 Live Attenuated Bordetella Strains as a Single Dose Vaccine Against Whooping cough Public/Granted day:2009-10-01
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