Invention Grant
- Patent Title: Tablet quickly disintegrating in the oral cavity and method for producing the same
- Patent Title (中): 片剂在口腔中快速崩解及其制备方法
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Application No.: US12997779Application Date: 2009-06-10
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Publication No.: US09119820B2Publication Date: 2015-09-01
- Inventor: Toru Fukushima , Takashi Shimizu , Teruko Yoshida
- Applicant: Toru Fukushima , Takashi Shimizu , Teruko Yoshida
- Applicant Address: JP Osaka
- Assignee: Sumitomo Dainippon Pharma Co., Ltd.
- Current Assignee: Sumitomo Dainippon Pharma Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2008-155300 20080613
- International Application: PCT/JP2009/060584 WO 20090610
- International Announcement: WO2009/151072 WO 20091217
- Main IPC: A61K31/198
- IPC: A61K31/198 ; A61K47/38 ; A61K47/36 ; A61K9/20 ; A61K9/00

Abstract:
The present invention relates to a tablet which is rapidly disintegrated in an oral cavity containing an active ingredient at a high content and a production method thereof. That is, the present invention provides a tablet which is rapidly disintegrated in an oral cavity containing an active ingredient in not less than 25% of the total weight, having a disintegration time of within 40 seconds and an absolute hardness of 1.8 N/mm2 or more, which is obtained by granulating a powder containing an active ingredient with a binding solution containing mannitol and corn-derived pregelatinized starch, mixing the resulting granules with at least one kind of a disintegrant selected from cornstarch, hydroxypropylstarch, carmellose and crospovidone, and compression molding the mixture.
Public/Granted literature
- US20110105615A1 TABLET QUICKLY DISINTEGRATING IN THE ORAL CAVITY AND METHOD FOR PRODUCING THE SAME Public/Granted day:2011-05-05
Information query
IPC分类: