Invention Grant
US09119830B2 Use of PACAP for the treatment of viral infections in aquatic organisms
有权
使用PACAP治疗水生生物体内的病毒感染
- Patent Title: Use of PACAP for the treatment of viral infections in aquatic organisms
- Patent Title (中): 使用PACAP治疗水生生物体内的病毒感染
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Application No.: US13989921Application Date: 2011-11-30
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Publication No.: US09119830B2Publication Date: 2015-09-01
- Inventor: Mario Pablo Estrada Garcia , Juna Maria Lugo Gonzalez , Yamila Carpio Gonzalez , Carolina Tafalla Piñeiro
- Applicant: Mario Pablo Estrada Garcia , Juna Maria Lugo Gonzalez , Yamila Carpio Gonzalez , Carolina Tafalla Piñeiro
- Applicant Address: CU La Habana
- Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
- Current Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
- Current Assignee Address: CU La Habana
- Agency: Hoffmann & Baron, LLP
- Priority: CU0233/10 20100112
- International Application: PCT/CU2011/000008 WO 20111130
- International Announcement: WO2012/072055 WO 20120607
- Main IPC: A61K9/08
- IPC: A61K9/08 ; A61K31/7056 ; A61K38/22 ; A61K9/00 ; A61K9/51
Abstract:
The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR.
Public/Granted literature
- US20140087998A1 USE OF PACAP FOR THE TREATMENT VIRAL INFECTIONS IN AQUATIC ORGANISMS Public/Granted day:2014-03-27
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