Invention Grant
US09119882B2 Volatile distillate by-product of mint oil that promotes absorption and/or bioavailability of compounds of bio-medical and nutritional interest
有权
薄荷油的挥发性馏出物副产物,促进生物医学和营养兴趣化合物的吸收和/或生物利用度
- Patent Title: Volatile distillate by-product of mint oil that promotes absorption and/or bioavailability of compounds of bio-medical and nutritional interest
- Patent Title (中): 薄荷油的挥发性馏出物副产物,促进生物医学和营养兴趣化合物的吸收和/或生物利用度
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Application No.: US13897545Application Date: 2013-05-20
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Publication No.: US09119882B2Publication Date: 2015-09-01
- Inventor: John Westcott Finley , John Weldon Finley , Igor Mezine , James M. Kehrer, II , Robert J. Justice, II
- Applicant: Flavor Liquidating (G) Corporation (new name of A.M. Todd Group, Inc.)
- Applicant Address: US MI Kalamazoo
- Assignee: Flavor Liquidating (G) Corporation (new name for A. M. Todd Group, Inc.)
- Current Assignee: Flavor Liquidating (G) Corporation (new name for A. M. Todd Group, Inc.)
- Current Assignee Address: US MI Kalamazoo
- Agent Thaddius J. Carvis
- Main IPC: A61K36/534
- IPC: A61K36/534 ; A61K47/46 ; A61K31/122 ; A61K45/06 ; A61K47/06 ; A61K47/08 ; A61K47/10

Abstract:
Disclosed is an adjuvant for improving the bioavailability of bioactive compositions. The adjuvant is prepared from a byproduct of mint flavor production. In vitro and in vivo testing confirms effectiveness. The adjuvant contains a mixture of compounds which is effective to improve the oral bioavailability of a bioactive composition normally having limited absorptivity, and it comprises a mixture of nonpolar compounds and compounds with some polar characteristics. In preferred form the nonpolar compounds comprise compounds selected from a group that includes terpene hydrocarbons and terpene derivatives and the compounds with some polar characteristics comprise compounds selected from a group that includes aldehydes, alcohols and ketones. The preferred compositions will have a ratio of nonpolar compounds and compounds with some polar characteristics is within the range of from 5:1 to 20:1. The adjuvants can enhance delivery of CoQ10 and other bioactive compositions, such as carotenoids (e.g., β-carotene), curcuminoids, lycopene, resveratrol, flavonoids and other phenolic compounds, organosulfur compounds, saponins, sterols, stanols, and mixtures of at least two of these, to the interior cellular environment, including organelles, such as the mitochondria.
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