Invention Grant
US09120738B2 Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
有权
比马前列素酸的结晶形式，制备方法及其使用方法
- Patent Title: Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
- Patent Title (中): 比马前列素酸的结晶形式，制备方法及其使用方法
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Application No.: US14136914Application Date: 2013-12-20
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Publication No.: US09120738B2Publication Date: 2015-09-01
- Inventor: Ke Wu , Shaoxin Feng , Thomas K. Karami , Scott W. Smith
- Applicant: ALLERGAN, INC.
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Jonathan Y. Bass
- Main IPC: C07C59/54
- IPC: C07C59/54
Abstract:
The invention provides new crystalline forms of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid. This compound is commonly referred to as “bimatoprost acid.” The novel crystalline forms are designated forms I, II, and III. The invention crystalline forms are useful for solid ocular implant formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension. In addition, invention crystalline forms are useful for solid or semisolid dosage formulations used to treat ocular hypertension.
Public/Granted literature
- US20140187636A1 CRYSTALLINE FORMS OF BIMATOPROST ACID, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF Public/Granted day:2014-07-03
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