Invention Grant
- Patent Title: Neprilysin inhibitors
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Application No.: US14024974Application Date: 2013-09-12
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Publication No.: US09120758B2Publication Date: 2015-09-01
- Inventor: Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
- Applicant: Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah
- Main IPC: C07D231/14
- IPC: C07D231/14 ; C07D401/06 ; C07D261/18 ; C07D249/10 ; C07D471/04 ; C07D257/04 ; C07D263/34 ; C07C281/02 ; C07D231/20 ; C07D231/22 ; C07D231/40 ; C07D237/24 ; C07D239/36 ; C07D239/54 ; C07D249/04 ; C07D249/12 ; C07D249/18 ; C07D263/38 ; C07D277/56 ; C07D401/04 ; C07D403/04 ; C07D403/06 ; C07D413/04 ; C07D239/28 ; C07D239/34 ; C07D239/52
Abstract:
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Public/Granted literature
- US20140011997A1 NEPRILYSIN INHIBITORS Public/Granted day:2014-01-09
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