Invention Grant
US09120768B2 Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing
有权
用于治疗囊性纤维化的组合物和方法以及与异常蛋白质细胞加工相关的疾病
- Patent Title: Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing
- Patent Title (中): 用于治疗囊性纤维化的组合物和方法以及与异常蛋白质细胞加工相关的疾病
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Application No.: US13817848Application Date: 2011-08-19
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Publication No.: US09120768B2Publication Date: 2015-09-01
- Inventor: Daniela Rotin , Agata Trzcinska-Daneluti
- Applicant: Daniela Rotin , Agata Trzcinska-Daneluti
- Applicant Address: CA Toronto, Ontario
- Assignee: The Hospital for Sick Children
- Current Assignee: The Hospital for Sick Children
- Current Assignee Address: CA Toronto, Ontario
- Agency: Bereskin & Parr LLP/S.E.N.C.R.L., s.r.l.
- International Application: PCT/CA2011/000934 WO 20110819
- International Announcement: WO2012/021974 WO 20120223
- Main IPC: C07D403/06
- IPC: C07D403/06 ; C07D313/00 ; A61K31/015 ; A61K31/404
Abstract:
The disclosure relates to resorcylic acid lactones and indolinone-containing compounds for use in treatment of diseases associated with aberrant protein processing, such as cystic fibrosis (CF; mucoviscidosis). The disclosure more generally relates to treatment of aberrant protein processing, such as errors in protein folding, trafficking or post-translational modification.
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