Invention Grant
US09120769B2 Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
有权
六氢茚基吡啶和八氢苯并喹啉的芳基和杂芳基羰基衍生物
- Patent Title: Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
- Patent Title (中): 六氢茚基吡啶和八氢苯并喹啉的芳基和杂芳基羰基衍生物
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Application No.: US14190899Application Date: 2014-02-26
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Publication No.: US09120769B2Publication Date: 2015-09-01
- Inventor: Matthias Eckhardt , Hans-Juergen Martin , Martin Schuehle , Sandra Sick , Bing Shiou Yang
- Applicant: Boehringer Ingelheim International GmbH
- Applicant Address: DE
- Assignee: Boehringer-Ingelheim International GmbH
- Current Assignee: Boehringer-Ingelheim International GmbH
- Current Assignee Address: DE
- Agency: McCarter & English LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- Priority: WOPCT/US2010/055586 20101105
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D401/06
Abstract:
The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
Public/Granted literature
- US20140249174A1 ARYL-AND HETEROARYLCARBONYL DERIVATIVES OF HEXAHYDROINDENOPYRIDINE AND OCTAHYDROBENZOQUINOLINE Public/Granted day:2014-09-04
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