Invention Grant
- Patent Title: Method for preparation of iloperidone and crystallization method thereof
- Patent Title (中): 伊立替哌啶的制备方法及其结晶方法
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Application No.: US14191270Application Date: 2014-02-26
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Publication No.: US09120782B2Publication Date: 2015-09-01
- Inventor: Shiwei Zhou , Feng Jian
- Applicant: Zhejiang Huahai Pharmaceutical Co., Ltd.
- Applicant Address: CN Zhejiang
- Assignee: Zhejiang Huahai Pharmaceutical Co., Ltd.
- Current Assignee: Zhejiang Huahai Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Zhejiang
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: CN200910178691 20090919; CN200910225973 20091121
- Main IPC: C07D413/04
- IPC: C07D413/04

Abstract:
A method for preparation of iloperidone is provided which comprises reacting 6-fluoro-3-(4-piperidinyl)-1,2-benzoisoxazole hydrochloride with 1-[4-(3-chloropropoxyl)-3-methoxyphenyl]ethyl ketone in an inorganic alkaline aqueous solution. A crystallization method of iloperidone is also provided which comprises adding seed crystal to the iloperidone solution in ethyl acetate, and then iloperidone crystal is obtained with high purity by controlling the temperature and the stirring speed.
Public/Granted literature
- US20140179927A1 METHOD FOR PREPARATION OF ILOPERIDONE AND CRYSTALLIZATION METHOD THEREOF Public/Granted day:2014-06-26
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