Invention Grant
US09120800B2 Process for the preparation of oxymorphone alkaloid and oxymorphone salts
有权
羟吗啡酮生物碱和羟吗啡酮盐的制备方法
- Patent Title: Process for the preparation of oxymorphone alkaloid and oxymorphone salts
- Patent Title (中): 羟吗啡酮生物碱和羟吗啡酮盐的制备方法
-
Application No.: US14173314Application Date: 2014-02-05
-
Publication No.: US09120800B2Publication Date: 2015-09-01
- Inventor: Ewart Grant , Brian Heinrich , Saroop Matharu , Nicolas Archer
- Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
- Applicant Address: GB London
- Assignee: Johnson Matthey Public Limited Company
- Current Assignee: Johnson Matthey Public Limited Company
- Current Assignee Address: GB London
- Main IPC: C07D489/08
- IPC: C07D489/08 ; C07D489/02
Abstract:
The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6α-oxymorphol produced is ≦3.00 area % as determined by HPLC.
Public/Granted literature
- US20150038715A1 PROCESS Public/Granted day:2015-02-05
Information query
