Invention Grant
US09120804B2 8-substituted 2-amino-[1,2,4] triazolo [1, 5-A] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors
有权
8-取代的2-氨基 - [1,2,4]三唑并[1,5-A]吡嗪作为Syk酪氨酸激酶抑制剂和GCN2丝氨酸激酶抑制剂
![8-substituted 2-amino-[1,2,4] triazolo [1, 5-A] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors](/docs/US/2015-09-01/US09120804B2/abs.jpg.600x600.jpg)
- Patent Title: 8-substituted 2-amino-[1,2,4] triazolo [1, 5-A] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors
- Patent Title (中): 8-取代的2-氨基 - [1,2,4]三唑并[1,5-A]吡嗪作为Syk酪氨酸激酶抑制剂和GCN2丝氨酸激酶抑制剂
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Application No.: US14379316Application Date: 2013-01-22
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Publication No.: US09120804B2Publication Date: 2015-09-01
- Inventor: Carl Deutsch , Daniel Kuhn , Tatjana Ross , Lars Burgdorf
- Applicant: Merck Patent GmbH
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: EP12001153 20120221
- International Application: PCT/EP2013/000189 WO 20130122
- International Announcement: WO2013/124026 WO 20130829
- Main IPC: A61K31/536
- IPC: A61K31/536 ; A61K31/4985 ; C07D273/01 ; C07D265/14 ; C07D487/04 ; C07D519/00 ; A61K31/496 ; A61K31/519 ; A61K31/537 ; A61K31/5377 ; A61K31/5386 ; A61K31/55 ; A61K31/5513
![8-substituted 2-amino-[1,2,4] triazolo [1, 5-A] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors](/abs-image/US/2015/09/01/US09120804B2/abs.jpg.150x150.jpg)
Abstract:
Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus.
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