Invention Grant
US09120817B2 Process for preparing (4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′ ,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
有权
制备（4R，12aS）-7-甲氧基-4-甲基-6,8-二氧代-3,4,6,8,12,12a-六氢-2H-吡啶并[1'，2'：4,5 ]吡嗪并[2,1-b] [1,3]恶嗪-9-甲酸
![Process for preparing (4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′ ,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid](/docs/US/2015-09-01/US09120817B2/abs.jpg.600x600.jpg)
- Patent Title: Process for preparing (4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′ ,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
- Patent Title (中): 制备（4R，12aS）-7-甲氧基-4-甲基-6,8-二氧代-3,4,6,8,12,12a-六氢-2H-吡啶并[1'，2'：4,5 ]吡嗪并[2,1-b] [1,3]恶嗪-9-甲酸
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Application No.: US14513265Application Date: 2014-10-14
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Publication No.: US09120817B2Publication Date: 2015-09-01
- Inventor: Steven N. Goodman , Huan Wang , Douglas Mans , Matthew Kowalski
- Applicant: VIIV Healthcare Company
- Applicant Address: US DE Wilmington
- Assignee: VIIV HEALTHCARE COMPANY
- Current Assignee: VIIV HEALTHCARE COMPANY
- Current Assignee Address: US DE Wilmington
- Agent J. Scott Young
- Main IPC: C07D498/14
- IPC: C07D498/14 ; C07D213/68 ; C07D213/80
![Process for preparing (4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′ ,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid](/abs-image/US/2015/09/01/US09120817B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to processes for the preparation of (4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid by contacting a pyridinone carboxylic acid aldehyde with (3R)-3-amino-1-butanol.
Public/Granted literature
- US20150057444A1 Process for Preparing Pyridinone Carboxylic Acid Aldehydes Public/Granted day:2015-02-26
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