Invention Grant
- Patent Title: Cyclic amine derivatives as EP4 receptor agonists
- Patent Title (中): 环胺衍生物作为EP4受体激动剂
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Application No.: US14127474Application Date: 2011-07-04
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Publication No.: US09120824B2Publication Date: 2015-09-01
- Inventor: Manuela Borriello , Sabrina Pucci , Luigi Piero Stasi , Lucio Rovati
- Applicant: Manuela Borriello , Sabrina Pucci , Luigi Piero Stasi , Lucio Rovati
- Applicant Address: IT Monza
- Assignee: ROTTAPHARM BIOTECH S.R.L.
- Current Assignee: ROTTAPHARM BIOTECH S.R.L.
- Current Assignee Address: IT Monza
- Agency: Ohlandt Greeley Ruggiero & Perle L.L.P.
- International Application: PCT/EP2011/061229 WO 20110704
- International Announcement: WO2013/004291 WO 20130110
- Main IPC: C07F1/02
- IPC: C07F1/02 ; C07D207/16 ; C07D211/60
Abstract:
There is described a group of novel cyclic amine derivative compounds having an EP4 receptor agonistic activity.Specifically, the compounds according to the invention are provided with analgesic, antinflammatory, antiglaucoma activity, and also with anti-osteoporosis and antiulcerative activity.The present invention therefore relates to novel cyclic amine derivative compounds, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, inter alia for the treatment or alleviation of Prostaglandin E mediated diseases such as pain, glaucoma, ulcerative colitis and osteoporosis.
Public/Granted literature
- US20140243373A1 CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR AGONISTS Public/Granted day:2014-08-28
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