Invention Grant
US09120866B2 DNA sequence and preparation of grass pollen allergen Phl p 4 by recombinant methods
有权
DNA重组方法制备草花粉过敏原Phl p4
- Patent Title: DNA sequence and preparation of grass pollen allergen Phl p 4 by recombinant methods
- Patent Title (中): DNA重组方法制备草花粉过敏原Phl p4
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Application No.: US13034210Application Date: 2011-02-24
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Publication No.: US09120866B2Publication Date: 2015-09-01
- Inventor: Helmut Fiebig , Andreas Nandy , Roland Suck , Oliver Cromwell , Arnd Petersen , Wolf-Meinhard Becker
- Applicant: Helmut Fiebig , Andreas Nandy , Roland Suck , Oliver Cromwell , Arnd Petersen , Wolf-Meinhard Becker
- Applicant Address: DE Darmstadt
- Assignee: MERCK PATENT GMBH
- Current Assignee: MERCK PATENT GMBH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: EP02013953 20020625
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K48/00 ; C07H21/02 ; C07H21/04 ; C12N1/12 ; C12N1/20 ; C12N15/00 ; C12N15/09 ; C12P21/04 ; C12P21/06 ; C07K14/415 ; G01N33/68 ; A61K31/7088 ; A61K39/36 ; A61K39/39 ; A61K45/06 ; A61K38/00
Abstract:
The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention also covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilized for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.
Public/Granted literature
- US20120288526A1 DNA SEQUENCE AND PREPARATION OF GRASS POLLEN ALLERGEN PHL P4 BY RECOMBINANT METHODS Public/Granted day:2012-11-15
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