Invention Grant
- Patent Title: Method for preparing polylactate and copolymer thereof using a mutant microorganism with enhanced polylactate, and the copolymer producing capability thereof
- Patent Title (中): 使用具有增强的聚乳酸的突变微生物制备聚乳酸的方法及其共聚物及其共聚物生产能力
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Application No.: US13001001Application Date: 2009-06-24
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Publication No.: US09120891B2Publication Date: 2015-09-01
- Inventor: Sang Yup Lee , Yu Kyung Jung , Taek Ho Yang , Si Jae Park , Tae Wan Kim
- Applicant: Sang Yup Lee , Yu Kyung Jung , Taek Ho Yang , Si Jae Park , Tae Wan Kim
- Applicant Address: KR Seoul KR Daejeon
- Assignee: LG CHEM, LTD.,KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: LG CHEM, LTD.,KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Seoul KR Daejeon
- Agency: Dentons US LLP
- Priority: KR10-2008-0059779 20080624
- International Application: PCT/KR2009/003389 WO 20090624
- International Announcement: WO2009/157702 WO 20091230
- Main IPC: C12P7/18
- IPC: C12P7/18 ; C12P7/42 ; C12N1/20 ; C12N15/74 ; C07H21/04 ; C08G63/06 ; C12P7/62 ; C12P21/02
Abstract:
Provided is a method of preparing polylactate (PLA) or a copolymer thereof using a mutant microorganism in which a gene participating in a coenzyme A (CoA) donor- and lactate-producing pathway is genetically manipulated to increase the productivity of a CoA donor and lactate. Amounts of the CoA donor and the lactate are simultaneously increased in a microbial metabolic pathway to enable effective biosynthesis of PLA and a hydroxyalkanoate-lactate copolymer having a high content of lactate, which is industrially useful.
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