Invention Grant
- Patent Title: Methods and compositions for enhancing the efficacy and specificity of RNA silencing
- Patent Title (中): 提高RNA沉默功效和特异性的方法和组合物
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Application No.: US13654199Application Date: 2012-10-17
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Publication No.: US09121018B2Publication Date: 2015-09-01
- Inventor: Phillip D. Zamore , Gyorgy Hutvagner , Dianne Schwarz , Martin Simard
- Applicant: UNIVERSITY OF MASSACHUSETTS
- Applicant Address: US MA Boston
- Assignee: University of Massachusetts
- Current Assignee: University of Massachusetts
- Current Assignee Address: US MA Boston
- Agency: Lathrop & Gage LLP
- Agent James H. Velema, Esq.
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113 ; A61K38/00 ; A61K48/00
Abstract:
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
Public/Granted literature
- US20130309767A1 METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING Public/Granted day:2013-11-21
Information query
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