Invention Grant
- Patent Title: Yeast strain and screening method for identifying inhibitors of the expression of the hexose transporter genes by a positive phenotype
- Patent Title (中): 通过阳性表型鉴定己糖转运蛋白基因表达的抑制剂的酵母菌株和筛选方法
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Application No.: US11791704Application Date: 2005-11-25
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Publication No.: US09121026B2Publication Date: 2015-09-01
- Inventor: Milan Höfer , Jost Ludwig , Petra Schwanewilm , Julius Subik
- Applicant: Milan Höfer , Jost Ludwig , Petra Schwanewilm , Julius Subik
- Applicant Address: DE Meckenheim CZ Ceske Budejovice
- Assignee: Milan Hofer,The South Bohemian University
- Current Assignee: Milan Hofer,The South Bohemian University
- Current Assignee Address: DE Meckenheim CZ Ceske Budejovice
- Agency: Ballard Spahr LLP
- Priority: EP04106160 20041129
- International Application: PCT/EP2005/056216 WO 20051125
- International Announcement: WO2006/056597 WO 20060601
- Main IPC: C12N15/81
- IPC: C12N15/81 ; C07K14/39 ; C07H21/02
Abstract:
The present invention provides screening procedures for identifying inhibitors of components of regulatory networks by a positive phenotype and modified yeast cell lines suitable for said screening. The screening procedures are especially suited to screen for substances that re-sensitize resistant pathogenic microorganisms or tumor cells by suspending the expression of resistance-relevant genes. The invention further provides methods for constructing said cell lines and their use in screening systems.
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