An internal combustion engine includes an engine defining a plurality of cylinders including full-time active cylinders and cylinders capable of being deactivated. A turbocharger system having a high pressure turbocharger in communication with the exhaust passages from the full-time active cylinders and a low pressure turbocharger in communication with the exhaust passages from the cylinders capable of being deactivated. A control valve is provided in communication with the exhaust passages from the full-time active cylinders and being operable in an open position to allow exhaust gases from the full-time active cylinders to pass through the second turbocharger along with the exhaust gasses from the cylinders capable of being deactivated, and being operable in a closed position to direct exhaust gases from the full-time active cylinders to pass through the first turbocharger.