Invention Grant
US09121855B2 Method for the detection of HIV-1 antibodies utilizing a peptide containing a novel gp41 epitope
有权
使用含有新gp41表位的肽检测HIV-1抗体的方法
- Patent Title: Method for the detection of HIV-1 antibodies utilizing a peptide containing a novel gp41 epitope
- Patent Title (中): 使用含有新gp41表位的肽检测HIV-1抗体的方法
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Application No.: US12977411Application Date: 2010-12-23
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Publication No.: US09121855B2Publication Date: 2015-09-01
- Inventor: Hana Golding , Surender Khurana
- Applicant: Hana Golding , Surender Khurana
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Baker & Hostetler, LLP
- Main IPC: G01N33/68
- IPC: G01N33/68 ; G01N33/569 ; C07K14/16 ; C07K14/005
Abstract:
This invention concerns methods for detecting the presence of an anti-HIV-1 antibody in a biological sample, the method comprising conducting an immunoassay comprising: (a) contacting the biological sample with at least one epitope that is recognized by the anti-HIV-1 antibody, wherein the contacting being under conditions sufficient to permit the anti-HIV-1 antibody if present in the sample to bind to the epitope and form an epitope-anti-HIV-1 antibody complex; (b) contacting the formed epitope-anti-HIV-1 antibody complex with an anti-HIV-1 antibody binding molecule, the contacting being under conditions sufficient to permit the anti- HIV-1 antibody binding molecule to bind to anti-HIV-1 antibody of the formed epitope-anti-HIV-1 antibody complex and form an extended complex; and (c) determining the presence or concentration of the anti-HIV-1 antibody in the biological sample by determining the presence or concentration of the formed extended complex; the epitope being present on a peptide comprising SEQ ID No. 55.
Public/Granted literature
- US20130143202A1 COMPOSITIONS AND METHODS FOR THE DETECTION OF HIV-1/HIV-2 INFECTION Public/Granted day:2013-06-06
Information query
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